Publications: S. Nikita, S. Mishra, K. Gupta, V. Runkana, J. Gomes, A.S. Rathore, Advances in bioreactor control for production of biotherapeutic products, Biotechnology and Bioengineering, (2023) https://doi.org/10.1002/bit.28346.
S. Mishra, V. Kumar, J. Sarkar, A.S. Rathore, Mixing and mass transfer in production scale mammalian cell culture reactor using coupled CFD-species transport-PBM validation, Chemical Engineering Science, 267 (2023) 118323.
N. Nitika, G. Thakur, A.S. Rathore, Continuous manufacturing of monoclonal antibodies: Dynamic control of multiple integrated polishing chromatography steps using BioSMB, Journal of Chromatography A, 1690 (2023) 463784.
S. Sheth, L. Vashishta, R. Goyal, A. Rathore, N. Chirmule, On the manufacturers of biosimilars in Asia, Clinical Pharmacology & Therapeutics, 113 (2023) 23-26.
R. Jain, J. Subramanian, A.S. Rathore, A review of therapeutic failures in late-stage clinical trials, Expert Opinion on Pharmacotherapy, (2022) doi.org/10.1080/14656566.2022.2161366.
K.N. Mihooliya, N. Nitika, R. Bhambure, A.S. Rathore, Post‐refolding stability considerations for optimization of in‐vitro refolding: L‐asparaginase as a case study, Biotechnology Journal, (2022) 2200505.
A.S. Rathore, S. Joshi, N. Nupur, S. Nikita, S. Bhattacharya, S. Roy, Taking the individual bias out of examining comparability of biosimilars: A case study on monoclonal antibody therapeutics, International Journal of Biological Macromolecules, 227 (2023) 124-133.
A. Tiwari, V.S. Masampally, A. Agarwal, A.S. Rathore, Digital twin of a continuous chromatography process for mAb purification: design and model‐based control, Biotechnology and Bioengineering, 120 (2022) 748-766.
G.B. Hubli, S. Banerjee, A.S. Rathore, Near-infrared spectroscopy based monitoring of all 20 amino acids in mammalian cell culture broth, Talanta, 254 (2023) 124187.
A.S. Rathore, S. Nikita, N.G. Jesubalan, Digitization in bioprocessing: The role of soft sensors in monitoring and control of downstream processing for production of biotherapeutic products, Biosensors and Bioelectronics: X, 12 (2022) 100263.
A. Rathore, F. Shereef, Innovating manufacturing technology in emerging economies, Nature Biotechnology, 40 (2022) 1714-1716.
G. Thakur, V. Bansode, A.S. Rathore, Continuous manufacturing of monoclonal antibodies: Automated downstream control strategy for dynamic handling of titer variations, Journal of Chromatography A, 1682 (2022) 463496.
A. Tiwari, V. Bansode, A.S. Rathore, Application of advanced machine learning algorithms for anomaly detection and quantitative prediction in protein A chromatography, Journal of Chromatography A, 1682 (2022) 463486.
D. Sarin, S. Kumar, A.S. Rathore, Multiattribute monitoring of charge-based heterogeneity of recombinant monoclonal antibodies using 2D HIC-WCX-MS, Analytical Chemistry, 94 (2022) 15018-15026.
D. Kumar, N. Gangwar, A.S. Rathore, M. Ramteke, Multi-objective optimization of monoclonal antibody production in bioreactor, Chemical Engineering and Processing-Process Intensification, 180 (2022) 108720.
R.P. Mishra, S. Gupta, A.S. Rathore, G. Goel, Multi-level high-throughput screening for discovery of ligands that inhibit insulin aggregation, Molecular Pharmaceutics, 19 (2022) 3770-3783.
A.S. Rathore, G. Thakur, N. Kateja, Continuous integrated manufacturing for biopharmaceuticals: A new paradigm or an empty promise?, Biotechnology and Bioengineering, 120 (2022) 333-351.
A.S. Rathore, S. Nikita, G. Thakur, S. Mishra, Artificial intelligence and machine learning applications in biopharmaceutical manufacturing, Trends in Biotechnology, (2022). doi.org/10.1016/j.tibtech.2022.08.007.
R. Sharma, A. Anupa, N. Kateja, A.S. Rathore, Optimization of the in-vitro refolding of biotherapeutic Fab Ranibizumab, Biochemical Engineering Journal, 187 (2022) 108601.
L.K. Shekhawat, A. Tiwari, S. Yamamoto, A.S. Rathore, An accelerated approach for mechanistic model based prediction of linear gradient elution ion-exchange chromatography of proteins, Journal of Chromatography A, 1680 (2022) 463423.
S. Gupta, K. Upadhyay, C. Schöneich, A.S. Rathore, Impact of various factors on the kinetics of non-enzymatic fragmentation of a monoclonal antibody, European Journal of Pharmaceutics and Biopharmaceutics, 178 (2022) 131-139.
S. Nikita, G. Thakur, N.G. Jesubalan, A. Kulkarni, V.B. Yezhuvath, A.S. Rathore, AI-ML applications in bioprocessing: ML as an enabler of real time quality prediction in continuous manufacturing of mAbs, Computers & Chemical Engineering, 164 (2022) 107896.
A. Mishra, A.S. Rathore, RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2, Journal of Biomolecular Structure and Dynamics, 40 (2022) 6039-6051.
S. Gupta, M. Mittal, A.S. Rathore, Atomic layer deposition coating on the surface of active pharmaceutical ingredients to reduce surface charge build-up, ACS Applied Materials & Interfaces, 14 (2022) 27195-27202.
H. Chhabra, M.C. Mouslim, S. Kashiramka, A.S. Rathore, Dynamics of biosimilar uptake in emerging markets, Expert Opinion on Biological Therapy, (2022). 679-688.
N. Gangwar, P. Priyanka, A.S. Rathore, Achieving charge variant profile of innovator molecule during development of monoclonal antibody based biosimilars–Use of media components, Biochemical Engineering Journal, 182 (2022) 108438.
S.K. Singh, D. Kumar, S. Nagpal, S.K. Dubey, A.S. Rathore, A charge variant of bevacizumab offers enhanced FcRn-dependent pharmacokinetic half life and efficacy, Pharmaceutical Research, 39 (2022) 851-865.
M. Mittal, S. Gupta, A.S. Rathore, Raman spectroscopy as process analytical technology tool for monitoring atomic layer deposition (ALD) of drug particles, Materials Chemistry and Physics, 282 (2022) 125976.
A. Shrivastava, S. Joshi, A. Guttman, A.S. Rathore, N-Glycosylation of monoclonal antibody therapeutics: A comprehensive review on significance and characterization, Analytica Chimica Acta, 1209 (2022) 339828.
R.S Patil, A. Anupa, J.A. Gupta, A.S. Rathore, Challenges in expression and purification of functional Fab fragments in E. coli: Current strategies and perspectives, Fermentation, 8 (2022) 175.
N. Swaminathan, P. Priyanka, A.S. Rathore, S. Sivaprakasam, S. Subbiah, Cole‐Cole modeling of real‐time capacitance data for estimation of cell physiological properties in recombinant Escherichia coli cultivation, Biotechnology and Bioengineering, 119 (2022) 922-935.
N. Nupur, S. Joshi, D. GUILLARME, A.S. Rathore, Analytical similarity assessment of biosimilars: Global regulatory landscape, recent studies and major advancements in orthogonal platforms, Frontiers in Bioengineering and Biotechnology, 10 (2022) 1-23.
A.S. Rathore, H. Malani, Need for a risk-based control strategy for managing glycosylation profile for biosimilar products, Expert Opinion on Biological Therapy, 22 (2022) 123-131.
A.S. Rathore, J.G. Stevenson, H. Chhabra, C. Maharana, The global landscape on interchangeability of biosimilars, Expert Opinion on Biological Therapy, 22 (2022) 133-148.
W.H. Khan, N. Khan, A. Mishra, S. Gupta, V. Bansode, D. Mehta, R. Bhambure, A.S. Rathore, Dimerization of SARS-CoV-2 nucleocapsid protein affects sensitivity of ELISA based diagnostics of COVID-19, International Journal of Biological Macromolecules, 200 (2022) 428-437.
A.S. Rathore, A.L. Zydney, A. Anupa, S. Nikita, N. Gangwar, Enablers of continuous processing of biotherapeutic products, Trends in Biotechnology, 40 (2022) 804-815.
J. Kumar, S.U. Bhat, A.S. Rathore, Slow post-induction specific growth rate enhances recombinant protein expression in Escherichia coli: Pramlintide multimer and ranibizumab production as case studies, Process Biochemistry, 114 (2022) 21-27.
P.P. Bhojane, S. Joshi, S.J. Sahoo, A.S. Rathore, Unexplored excipients in biotherapeutic formulations: Natural osmolytes as potential stabilizers against thermally induced aggregation of IgG1 biotherapeutics, AAPS PharmSciTech, 23 (2022) 1-12.
P. Priyanka, R.S. Patil, P. Meshram, J.A. Gupta, M. Banerjee, A.S. Rathore, Ethanol as additive enhances expression of Ranibizumab in Escherichia coli: Impact on cellular physiology and transcriptome, Process Biochemistry, 112 (2022) 167-176.
S. Banerjee, M.A. Afzal, P. Chokshi, A.S. Rathore, Mechanistic modelling of Chinese hamster ovary cell clarification using acoustic wave separator, Chemical Engineering Science, 246 (2021) 116894.
G. Thakur, A. S. Rathore, Modelling and optimization of single-pass tangential flow ultrafiltration for continuous manufacturing of monoclonal antibodies, Separation and Purification Technology, 276 (2021) 119341.
S. Sreenivasan, W. Jiskoot, A.S. Rathore, Rapid aggregation of therapeutic monoclonal antibodies by bubbling induced air/liquid interfacial and agitation stress at different conditions, European Journal of Pharmaceutics and Biopharmaceutics, 168 (2021) 97-109.
A. Mishra, W.H. Khan, A.S. Rathore, Synergistic effects of natural compounds toward inhibition of SARS-CoV-2 3CL protease, Journal of chemical information and modeling, 61 (2021) 5708-5718.
M. Mittal, Kritika Sharma, A. S. Rathore, Checking counterfeiting of pharmaceutical products by attenuated total reflection mid-infrared spectroscopy, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 255 (2021) 119710.
S. Kiruthika, R. Bhat, R. Dash, A. S. Rathore, P. Vivekanandan, B. Jayaram, A novel piperazine derivative that targets hepatitis B surface antigen effectively inhibits tenofovir resistant hepatitis B virus, Scientific Reports, 11 (2021) 1-13.
N. Nitika, H. Chhabra, A.S. Rathore, Raman spectroscopy for in situ, real time monitoring of protein aggregation in lyophilized biotherapeutic products, International Journal of Biological Macromolecules, 179 (2021) 309-313.
S. Mishra, V. Kumar, J. Sarkar, A.S. Rathore, CFD based mass transfer modeling of a single use bioreactor for production of monoclonal antibody biotherapeutics, Chemical Engineering Journal, 412 (2021) 128592.
G. Thakur, S. Thori, A.S Rathore, Implementing PAT for single-pass tangential flow ultrafiltration for continuous manufacturing of monoclonal antibodies, Journal of Membrane Science, 613 (2021) 118711.
V. Amritkar, S. Adat, V. Tejwani, A.S. Rathore, R. Bhambure, Engineering Staphylococcal Protein A for high-throughput affinity purification of monoclonal antibodies, Biotechnology Advances, 40 (2020) 107632.
A.S. Rathore, F. Shereef, The influence of domestic manufacturing capabilities on biologic pricing in emerging economies, Nature Biotechnology, 37(2019), 498-501.
M.C. Nweke, A.S. Rathore, D.G. Bracewell, Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture, Trends in Biotechnology, 36 (2018), 992-995.
