Dedicated to creating Best Practices for COMMERCIALIZATION of Biotechnology Therapeutic Products
Prof. Anurag S. Rathore
Department of Chemical Engineering
IIT Delhi, Hauz Khas
New Delhi, Delhi 110016
India
ph: +91-9650770650
fax: +91-1126596279
alt: +91-1126591098
asrathor
L. K. Shekhawat, J. Sarkar, R. Gupta, S. Hadpe, and A. S. Rathore, Application of CFD in Bioprocessing: Separation of mammalian cells using disc stack centrifuge during production of biotherapeutics, Journal of Biotechnology, 267 (2018) 1-11.
R. Bansal, S. Dhawan, S. Chatterjee, G. Maurya, V. Haridas, A. S. Rathore, Peptide dendrons as thermal stability amplifiers for IgG1 monoclonal antibody biotherapeutics, Bioconjugate Chemistry (2017) DOI: 10.1021/acs.bioconjchem.7b00389.
Sumit K. Singh, D. Kumar, and A. S. Rathore, Determination of Critical Quality Attributes for a Biotherapeutic in the QbD Paradigm: GCSF as a Case Study, The AAPS Journal, (2017) DOI https://doi.org/10.1208/s12248-017-0139-8.
N. Kateja, D. Kumar, A. Godara, V. Kumar, and A. S. Rathore, Integrated Chromatographic Platform for Simultaneous Separation of Charge Variants and Aggregates from Monoclonal Antibody Therapeutic Products, Biotechnology Journal (2017) DOI: 10.1002/biot.201700133.
P. Misra, A. Sinha, F. Q. Mir, A. S. Rathore, and A. Shukla A three plus three parameters mechanistic model for viral filtration, Biotechnology Progress (2017) DOI:10.1002/btpr.2523.
M. Pathak and A. S. Rathore, Implementation of a Fluorescence Based Process Analytical Technology Control of Fouling of Protein A Chromatography Resin, Journal of Chemical Technology and Biotechnology. 92 (2017) 2799–2807.
V. Kumar and A. S. Rathore, Mechanistic Modeling of Ion-Exchange Process Chromatography of Charge Variants of Monoclonal Antibody Products: Application for PAT Implementation, Biotechnology Journal (2017) DOI:10.1002/biot.201700286.
L. K. Shekhawat, M. Chandak and A. S. Rathore, Mechanistic modeling of hydrophobic interaction chromatography for purification of monoclonal antibody therapeutics: Process optimization in the quality by design paradigm, Journal of Chemical Technology and Biotechnology. 92 (2017) 2527–2537.
N. Kateja, H. Agarwal, V. Hebbi, and A. S. Rathore, Integrated continuous processing of proteins expressed as inclusion bodies: GCSF as a case study, Biotechnology Progress 33 (2017) 998-1009.
S. R. Hadpe, A. K. Sharma, V. V. Mohite and A. S. Rathore, ATF for cell culture harvest clarification: Mechanistic modelling and comparison with TFF, Journal of Chemical Technology and Biotechnology. 92 (2017) 732-740.
C. Komives, E. Sanchez, A. S. Rathore, B. White, M. Suntravat, M. Balderrama, A. Cifelli, V. Joshi, Opossum peptide that can neutralize rattlesnake venom is expressed in Escherichia coli, Biotechnology Progress (2016) in print.
R. Singh, R. Jindal, A. S. Rathore, and G. Goel, Equilibrium Ensembles for Insulin Folding from Bias-Exchange Metadynamicsts, Biophysical Journal 112 (20176) 1571-1585.
Preparative Chromatography for Separation of Proteins and Peptides, Ed. By A. Staby, S. Ahuja, and A. S. Rathore, Wiley Interscience, 2017.
BOOKS
Novel Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts, Ed. By C. Komives, W. Zhou and A. S. Rathore, Wiley Interscience, 2018.
Preparative Chromatography for Separation of Proteins and Peptides, Ed. By A. Staby, S. Ahuja, and A. S. Rathore, Wiley Interscience, 2017.
Process Validation in Manufacturing of Biopharmaceuticals, Edition 3, Ed. By A. S. Rathore and G. Sofer, Taylor and Francis, 2012.
Quality by Design for Biopharmaceuticals: Perspectives and Case Studies, Ed. by A. S. Rathore and R. Mhatre, Wiley Interscience, 2009, New Jersey.
Elements of Biopharmaceutical Production Series, Ed. By A. S. Rathore, Advanstar Communications, New York, 2007.
Process Validation in Manufacturing of Biopharmaceuticals, Ed. By A. S. Rathore and G. Sofer, CRC Press, 2005.
Electrokinetic phenomena: Principles and Applications in Analytical Chemistry and Microchip Technology, Ed. by A. S. Rathore and A. Guttman, Marcel Dekker, 2003.
Scale-up and Optimization in Preparative Chromatography, Ed. by A. S. Rathore and A. Velayudhan, Marcel Dekker, 2002.
“A formulation for stabilizing biotherapeutics”, Disclosure filed at the Indian Patent Office, 2017.
“Method for monitoring of foulants present on chromatographic resins using fluorescence probe”, Patent Application No. 201611015421, filed June 7, 2016 at the Indian Patent Office.
“A low cost process for production of snake antivenom peptide”, application PD015790IN, filed 20th March 2015 at the Indian Patent Office.
“An innovative coiled flow inverted reactor for continuous refolding of denatured recombinant proteins”, application 185/DEL/2015, filed 21st January 2015 at the Indian Patent Office.
“A process for purification of recombinant granulocyte colony stimulating factor”, Application 1880/DEL/2012, filed 19th June 2012 at the Indian Patent Office. PCT application 13/921891 filed 19th June 2013 at US Patent Office, Patent number 9422354.
“Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof”, application #20040048315, filed 26th August 2003, granted 3rd April 2012, Patent number 8148331.
“Methods for decreasing aggregate levels of pegylated growth hormone antagonists”, filed Sep 22nd 2003, granted 30 December 2008, Patent number 7470779.
TECHNOLOGIES DEVELOPED
An innovative coiled flow inverted reactor for continuous refolding of denatured recombinant proteins (patent application filed for US and for India)
Creation of a novel aqueous two phase extraction process for purification of biotech therapeutics (patent application filed for US and for India)
Creation of a novel single step process for purification of biotech therapeutics (patent application filed for US and for India)
CFD modeling of a helical coil heat exchanger to aid in scaleup from lab to manufacturing scale for Ranbaxy laboratories
Creation of a high throughput process development (HTPD) protocol for development of biotech processes for GE Healthcare
Proposed a novel approach for using multivariate data analysis (MVDA) for evaluating comparability of biotech processes and products for Dr Reddy Laboratories
Developed a process analytical technology (PAT) based control scheme for a process chromatography column for Biocon Ltd.
Creation of manufacturing process for Granulocyte Colony Stimulating Factor (GCSF), a biotech therapeutic - in negotiation with Indian biotech companies for licensing
PUBLICATIONS
K. B. Ramachandran, A. S. Rathore and S. K. Gupta, Modeling the effects of electrostatic interaction with reaction-generated pH change on the kinetics of immobilized enzymes, Chem. Eng. Journal, 57 (1995) B15-B21.
LECTURES
Copyright 2009 BiotechCMZ.com. All rights reserved.
Prof. Anurag S. Rathore
Department of Chemical Engineering
IIT Delhi, Hauz Khas
New Delhi, Delhi 110016
India
ph: +91-9650770650
fax: +91-1126596279
alt: +91-1126591098
asrathor